Assisted reproduction treatment

Reproductive outcome of a case with familial balanced translocation t(3;6): implications for genetic counseling

H. - G. Zhang, Liu, X. - Y., Hou, Y., Chen, S., Deng, S., and Liu, R. - Z., Reproductive outcome of a case with familial balanced translocation t(3;6): implications for genetic counseling, vol. 14, pp. 2809-2815, 2015.

Although it is known that parental carriers of structural chromosomal rearrangements are associated with recurrent pregnancy loss, subsequent natural pregnancies remain possible. We examined the reproductive outcome of a familial balanced translocation with t(3;6)(q12;q27). Karyotyping of the proband revealed 46,XY chromosomes with the balanced translocation t(3;6). The first 2 pregnancies resulted in spontaneous abortions. Based on the proband karyotype, his father and half-brother were subjected to cytogenetic analysis, and both showed 46,XY, t(3;6)(q12;q27).

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