Reproductive outcome of a case with familial balanced translocation t(3;6): implications for genetic counseling
“Reproductive outcome of a case with familial balanced translocation t(3;6): implications for genetic counseling”, vol. 14, pp. 2809-2815, 2015.
, Although it is known that parental carriers of structural chromosomal rearrangements are associated with recurrent pregnancy loss, subsequent natural pregnancies remain possible. We examined the reproductive outcome of a familial balanced translocation with t(3;6)(q12;q27). Karyotyping of the proband revealed 46,XY chromosomes with the balanced translocation t(3;6). The first 2 pregnancies resulted in spontaneous abortions. Based on the proband karyotype, his father and half-brother were subjected to cytogenetic analysis, and both showed 46,XY, t(3;6)(q12;q27).