Array comparative genomic hybridization

De novo interstitial deletion in the long arm of chromosome 11: a case report

L. L. Li, Zhang, H. G., Shao, X. G., Gao, J. C., Zhang, H. Y., Liu, R. Z., Li, L. L., Zhang, H. G., Shao, X. G., Gao, J. C., Zhang, H. Y., and Liu, R. Z., De novo interstitial deletion in the long arm of chromosome 11: a case report, vol. 15, p. -, 2016.

The 11q terminal deletion disorder is a rare genetic disorder associated with numerous clinical features. A few case reports have been made about de novo interstitial deletion of chromosome 11q. However, due to the heterogeneity in size and position of the deletions, a clear genotype-phenotype correlation is not easily made. Here we report a case interstitial 20.5-Mb deletion at chromosome 11q13.4q21, as confirmed by array comparative genomic hybridization.

Smallest critical region for microcephaly in a patient with mosaic ring chromosome 13

P. - H. Su, Chen, C. - P., Su, Y. - N., Chen, S. - J., Lin, L. - L., and Chen, J. - Y., Smallest critical region for microcephaly in a patient with mosaic ring chromosome 13, vol. 12. pp. 1311-1317, 2013.

A ring chromosome 13 or r(13) exhibits breakage and reunion at breakage points on the long and short arms of chromosome 13, with deletions of the chromosomal segments distal to the breakage points. The r(13) chromosome accounts for approximately 20% of ring chromosomes compatible with life. We describe a female patient with mental retardation, growth retardation, microcephaly, craniofacial dysmorphy, hearing impairment, and prolonged prothrombin time.

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