Apoptosis of leukemic cells

Significance of SODD expression in childhood acute lymphoblastic leukemia and its influence on chemotherapy

H. F. Tao, Liu, Y. S., Fang, J. L., Su, Y. Z., Chen, F. H., Zhou, L. Y., and Zhu, Y. S., Significance of SODD expression in childhood acute lymphoblastic leukemia and its influence on chemotherapy, vol. 13, pp. 2020-2031, 2014.

This study explored the clinical significance of silencer of death domain (SODD) expression in childhood acute lymphoblastic leukemia (ALL) and its influence on chemotherapy as well as the effect of SODD expression on apoptosis of leukemic cells. The expression of SODD proteins in different ALL groups was determined by immunocytochemistry. The SODD RNAi-interfering plasmid was constructed and transferred to Jurkat cells, and the effects of SODD expression on cell proliferation and apoptosis were analyzed using the MTT and FCM methods.

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