Apoptosis

O-naphthoquinone isolated from Capraria biflora L. induces selective cytotoxicity in tumor cell lines

G. G. Nde S. Wisintainer, Scola, G., Moura, S., Lemos, T. L. G., Pessoa, C., de Moraes, M. O., Souza, L. G. S., Roesch-Ely, M., and Henriques, J. A. P., O-naphthoquinone isolated from Capraria biflora L. induces selective cytotoxicity in tumor cell lines, vol. 14, pp. 17472-17481, 2015.

Biflorin is an o-naphthoquinone isolated from the roots of the plant Capraria biflora L. (Scrophulariaceae). In this study, the cytotoxic effects of biflorin were verified, and late apoptosis was detected in various cancer cell lines by in situ analysis. The cytotoxicity was further evaluated exclusively for 48 h of treatment in different tumor and non-tumor cell lines (Hep-2, HeLa, HT-29, A-375, and A-549, and HEK-293, respectively). The results indicated that biflorin induced selective cytotoxicity in tumor cells.

Mesenchymal stem cells from skin lesions of psoriasis patients promote proliferation and inhibit apoptosis of HaCaT cells

R. F. Liu, Wang, F., Wang, Q., Zhao, X. C., and Zhang, K. M., Mesenchymal stem cells from skin lesions of psoriasis patients promote proliferation and inhibit apoptosis of HaCaT cells, vol. 14. pp. 17758-17767, 2015.

Psoriasis is an inflammatory skin disease characterized by excessive proliferation and abnormal differentiation and apoptosis of keratinocytes (KCs). Mesenchymal stem cells (MSCs) from skin lesions of psoriasis patients demonstrate abnormal cytokine secretion, which may affect KC proliferation and apoptosis. Here, we explored how MSCs from skin lesions of psoriasis patients affect HaCaT cell proliferation and apoptosis. First, flow cytometry and multipotent differentiation methods were used to identify skin MSCs, which were then co-cultured with HaCaT cells.

Sevoflurane induces neurotoxicity in young mice through FAS/FASL signaling

Q. Song, Ma, Y. L., Song, J. Q., Chen, Q., Xia, G. S., Ma, J. Y., Feng, F., Fei, X. J., and Wang, Q. M., Sevoflurane induces neurotoxicity in young mice through FAS/FASL signaling, vol. 14, pp. 18059-18068, 2015.

Sevoflurane, the most widely used anesthetic in clinical practice, has been shown to induce apoptosis, inhibit neurogenesis, and cause learning and memory impairment in young mice. However, the underlying mechanism is still unknown. In this study, wild-type and the FAS- or FAS ligand (FASL)-knockout mice (age 7 days) were exposed to sevoflurane or pure oxygen. Western blotting was used to examine the expression of FAS protein.

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