Apoptosis

Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells

D. X. Li, Zhang, J., Zhang, Y., Zhao, P. W., and Yang, L. M., Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells, vol. 14, pp. 10553-10568, 2015.

Berberine (BBR) is a natural alkaloid with significant anti-tumor activity against many types of cancer cells. In this study, we investigated the molecular mechanisms employed by BBR to repress the proliferation and growth of skin squamous cell carcinoma A431 cells.

Xiayuxue decoction reduces renal injury by promoting macrophage apoptosis in hepatic cirrhotic rats

C. Liu, Cai, J., Cheng, Z., Dai, X., Tao, L., Zhang, J., and Xue, D., Xiayuxue decoction reduces renal injury by promoting macrophage apoptosis in hepatic cirrhotic rats, vol. 14, pp. 10760-10773, 2015.

Renal pathological changes in cirrhotic rat have not been extensively reported. The aim of this study was to investigate whether Xiayuxue decoction (XYXD) could attenuate renal injury induced by bile duct ligation (BDL), with special focus on the mechanisms promoting renal macrophage apoptosis. The rats were treated with BDL for 5 weeks and administered 0.36 g/kg XYXD intragastrically from day 1 of initiating BDL. Renal tissue was monitored by hematoxylin-eosin and Sirius red staining.

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