Apoptosis

Roles of osteocyte apoptosis in steroid-induced avascular necrosis of the femoral head

R. Bai, Feng, W., Liu, W. L., Zhao, Z. H. Q., Zhao, A. Q., Wang, Y., Wang, W. X., Sun, L., Wu, L. S. H., Cui, S. H. X., Bai, R., Feng, W., Liu, W. L., Zhao, Z. H. Q., Zhao, A. Q., Wang, Y., Wang, W. X., Sun, L., Wu, L. S. H., Cui, S. H. X., Bai, R., Feng, W., Liu, W. L., Zhao, Z. H. Q., Zhao, A. Q., Wang, Y., Wang, W. X., Sun, L., Wu, L. S. H., and Cui, S. H. X., Roles of osteocyte apoptosis in steroid-induced avascular necrosis of the femoral head, vol. 15, p. -, 2016.

An animal model of steroid-induced avascular necrosis of the femoral head (SANFH) was established to investigate the roles of osteocyte apoptosis in this process. Forty five-month-old male and female Japanese white rabbits were randomly divided into groups A (hormone + endotoxin), B (hormone alone), C (endotoxin alone), and D (blank control). Animals were sacrificed two and four weeks following the final treatment (N = 5 for each group at each time point). Bilateral femoral heads were fixed and decalcified, and empty lacunae were counted by hematoxylin staining.

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