We investigated the plasma hypersensitive C-reactive protein (hs-CRP), oxidized low-density lipoprotein (ox-LDL), and apelin levels in patients with hypertensive heart disease (HHD) plus coronary artery disease (CAD). Patients with hypertension hospitalized in Xuzhou Central Hospital were categorized into the HHD group and the HHD plus CAD group; 40 healthy subjects served as the control group. hs-CRP expression was determined with chemiluminescence. The expression of ox-LDL and apelin was analyzed with enzyme-linked immunosorbent assay.
We determined whether the blood pressure response to losartan in an older Chinese population with essential hypertension was associated with apelin gene polymorphisms. We genotyped the -1860T>C polymorphism of the apelin gene in a case-control study of 222 patients with hypertension and 250 controls.