Antigenotoxicity

Resistant starch: a functional food that prevents DNA damage and chemical carcinogenesis

S. D. Navarro, Mauro, M. O., Pesarini, J. R., Ogo, F. M., and Oliveira, R. J., Resistant starch: a functional food that prevents DNA damage and chemical carcinogenesis, vol. 14, pp. 1679-1691, 2015.

Resistant starch is formed from starch and its degradation products and is not digested or absorbed in the intestine; thus, it is characterized as a fiber. Because fiber intake is associated with the prevention of DNA damage and cancer, the potential antigenotoxic, antimutagenic, and anticarcinogenic capabilities of resistant starch from green banana flour were evaluated.

Protective effects of the antileishmanial extract of Tephrosia cinerea (L.) Pers. (Fabaceae) against cyclophosphamide-induced damage

A. C. S. Dias, Moreira, V. R., Almeida, L. P., Lima, M. I. S., Bezerra, J. L., Ribeiro, M. N. S., Nascimento, F. R. F., and Pereira, S. R. F., Protective effects of the antileishmanial extract of Tephrosia cinerea (L.) Pers. (Fabaceae) against cyclophosphamide-induced damage, vol. 13, pp. 9044-9055, 2014.

Tephrosia cinerea L. (Pers.) is a tropical species that exhibits antileishmanial activity in Leishmania amazonensis promastigote cultures and is commonly used to treat infections, inflammations, ulcers, nervous conditions, and diarrhea. However, no studies have investigated its effects on genetic material. Therefore, we evaluated the genotoxic potential, antigenotoxic potential, and cytotoxic effects of hydroalcoholic extracts of T. cinerea leaves.

Evaluation of genotoxic and cytotoxic effects of antileishmanial extract from Julocroton triqueter (Euphorbiaceae)

V. R. Moreira, Dias, A. C. S., Martins, A. R. P., Lima, M. I. S., Serra, I. C. P. B., Ribeiro, M. N. S., Nascimento, F. R. F., and Pereira, S. R. F., Evaluation of genotoxic and cytotoxic effects of antileishmanial extract from Julocroton triqueter (Euphorbiaceae), vol. 12, pp. 1132-1142, 2013.

Julocroton triqueter extracts have antileishmanial activity; however, the effect on genetic stability has not been studied. We evaluated genotoxic and cell death induction potential (in vitro and in vivo) of J. triqueter var. triqueter hydroalcoholic extracts, as well as their antigenotoxic potential in vivo. The in vitro genotoxic studies were performed using human leukocytes at four different concentrations.

Assessment of genotoxic, cytotoxic, and protective effects of Salacia crassifolia (Mart. Ex. Schult.) G. Don. stem bark fractions in mice

C. C. Carneiro, Silva, C. R., Menezes, A. C. S., Pérez, C. N., and Chen-Chen, L., Assessment of genotoxic, cytotoxic, and protective effects of Salacia crassifolia (Mart. Ex. Schult.) G. Don. stem bark fractions in mice, vol. 12, pp. 2167-2177, 2013.

Salacia crassifolia (Mart. Ex. Schult.) G. Don., popularly known in Brazil as "bacupari", "cascudo", and "saputá", is a shrub of the Celastraceae family that is unique to the Brazilian Cerrado region. In folk medicine, this plant has been mainly used to treat skin cancer and gastric ulcers. In the present study, the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic effects of S. crassifolia stem bark fractions (hexane, ethyl acetate, and hydroalcoholic extracts) were evaluated using the mouse bone marrow micronucleus test.

Antigenotoxic, and anticytotoxic activities of an ethanolic extract of Lafoensia pacari (Lythraceae) stem bark in bacteria and mice

D. C. S. Lima, Silva, C. R., Sampaio, B. L., de Paula, J. R., and Chen-Chen, L., Antigenotoxic, and anticytotoxic activities of an ethanolic extract of Lafoensia pacari (Lythraceae) stem bark in bacteria and mice, vol. 12, pp. 3887-3896, 2013.

Lafoensia pacari (Lythraceae), popularly known in Brazil as "pacari", is a small tree native to the Cerrado that is used in folk medicine to treat cancer and as an anti-inflammatory and cicatrizing agent. We evaluated the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic activities of an ethanol extract of L. pacari stem bark (EESB) using the Ames test and the mouse bone marrow micronucleus test.

Antigenotoxic and anticytotoxic activity of Duguetia furfuracea in bacteria and mice

C. R. Silva, Vieira, P. M., and Chen-Chen, L., Antigenotoxic and anticytotoxic activity of Duguetia furfuracea in bacteria and mice, vol. 12, pp. 3718-3725, 2013.

Duguetia furfuracea (St. Hil.) Benth & Hook f. (1862), popularly known as "sofre-do-rim-quem-quer" and "araticum-seco", is a shrub of the Annonaceae family that grows in several regions of Brazil. Infusions of its leaves and twigs are used in folk medicine to treat rheumatism and renal colic, whereas the seed powder is mixed with water to treat pediculosis. Studies on the plant have reported biological activities with cytotoxic, antitumoral, trypanocidal, leishmanicidal, antiplasmodial, and antiprotozoal effects.

Modulatory effect of Palicourea coriacea (Rubiaceae) against damage induced by doxorubicin in somatic cells of Drosophila melanogaster

D. C. S. Passos, Ferreira, H. D., Vieira, I. L. F. B., Nunes, W. B., Felício, L. P., Silva, E. M., Vale, C. R., Duarte, S. R., Silva, E. S., and Carvalho, S., Modulatory effect of Palicourea coriacea (Rubiaceae) against damage induced by doxorubicin in somatic cells of Drosophila melanogaster, vol. 9, pp. 1153-1162, 2010.

Palicourea coriacea, popularly known as “douradinha”, is a medicinal plant from the Brazilian Cerrado region used in folk medicine to treat kidney and urethral stones and kidney inflammation. We evaluated the cytotoxic, genotoxic, and possible antigenotoxic activities of an aqueous extract of P. coriacea on somatic cells of Drosophila melanogaster, using the somatic mutation and recombination test. We used third-stage larvae of D. melanogaster from a standard cross and a high bioactivation cross and tested 10 different doses of P.

Protective effects of β-carotene against the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster

C. D. Dias, Araújo, B. C., Dutra, E. S., and Nepomuceno, J. C., Protective effects of β-carotene against the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster, vol. 8, pp. 1367-1375, 2009.

β-carotene (BC), pro-vitamin A, is an efficient antioxidant, effective in the neutralization of oxygen reactive species, which cause serious damage to DNA. Various studies have been conducted on the effectiveness of BC for chemoprevention of cancer and heart disease. Doxorubicin is a chemotherapeutic agent used for cancer treatment that generates free radicals. We examined the effects of BC (1, 2 and 4 mg/mL) on the genotoxicity of doxorubicin (0.125 mg/mL), using the wing spot test in Drosophila melanogaster (somatic mutation and recombination test).

Antigenotoxic and antimutagenic potential of an annatto pigment (norbixin) against oxidative stress

A. C. T. S. Júnior, Asad, L. M. B. O., de Oliveira, E. B., Kovary, K., Asad, N. R., and Felzenszwalb, I., Antigenotoxic and antimutagenic potential of an annatto pigment (norbixin) against oxidative stress, vol. 4, pp. 94-99, 2005.

Carotenoids are 40-carbon molecules with conjugated double bonds, making them particularly effective for quenching free radicals. They have always been believed to possess anticancer properties, which could be due to their antioxidant potential. Norbixin is an unusual dicarboxylic water-soluble carotenoid present as a component in the pericarp of the seeds of Bixa orellana L. (from the Bixaceae family), a tropical shrub commonly found in Brazil.

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