Anti-therapy

High expression of HIF-2α and its anti-radiotherapy effect in lung cancer stem cells

J. C. Sun, He, F., Yi, W., Wan, M. H., Li, R., Wei, X., Wu, R., and Niu, D. L., High expression of HIF-2α and its anti-radiotherapy effect in lung cancer stem cells, vol. 14, pp. 18110-18120, 2015.

Hypoxia-inducible factor-2 alpha (HIF-2α) has been shown to regulate cell stemness, although the expression and effects of HIF-2α in lung cancer stem cells remained unclear. This study investigated HIF-2α expression in lung cancer stem cells, as well as the relationship between HIF-2α expression and radioresistance in lung cancer cells. Stem-like cells (CD133+) in the non-small-cell lung cancer cell line A549 were enriched by serum-free culture conditions, and CD133+ cells were sorted via fluorescence-activated cell sorting.

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