Anemia

Abnormal hemoglobin phenotypes in carriers of mild anemia in Latin America

P. J. A. Zamaro and Bonini-Domingos, C. R., Abnormal hemoglobin phenotypes in carriers of mild anemia in Latin America, vol. 9. pp. 425-428, 2010.

We looked for abnormal hemoglobins in blood samples sent for diagnosis of anemia. Identification of the hemoglobins was made using electrophoretic, chromatographic and molecular procedures. The 2020 blood samples were of patients from various regions of Brazil and from some other Latin American countries. Among the abnormal hemoglobins that we found, 3.5% are known to be rare, while 51% had an electrophoretic profile similar to that of Hb S at alkaline pH. Differentiation was possible only by combining electrophoretic and chromatographic methods.

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