Androgen receptor

Molecular cloning, characterization, and expression profiles of androgen receptors in spotted scat (Scatophagus argus)

H. P. Chen, Deng, S. P., Dai, M. L., Zhu, C. H., Li, G. L., Chen, H. P., Deng, S. P., Dai, M. L., Zhu, C. H., Li, G. L., Chen, H. P., Deng, S. P., Dai, M. L., Zhu, C. H., and Li, G. L., “Molecular cloning, characterization, and expression profiles of androgen receptors in spotted scat (Scatophagus argus)”, vol. 15, p. -, 2016.

Androgen plays critical roles in vertebrate reproductive systems via androgen receptors (ARs). In the present study, the full-length spotted scat (Scatophagus argus) androgen receptor (sAR) cDNA sequence was cloned from testis. The sAR cDNA measured 2448 bp in length with an open-reading frame of 2289 bp, encoding 763 amino acids. Amino acid alignment analyses showed that the sARs exhibited highly evolutionary conserved functional domains. Phylogenetically, the sARs clustered within the ARβ common vertebrate group.

Androgen receptor (CAG)n polymorphisms and breast cancer risk in a Han Chinese population

J. Dang, Peng, L., Zhong, H. J., and Huo, Z. H., “Androgen receptor (CAG)n polymorphisms and breast cancer risk in a Han Chinese population”, vol. 14, pp. 10258-10266, 2015.

The androgen receptor (AR) is involved in the differentiation and growth of breast cancer. Genetic markers in the AR gene have a plausible role in modulating the risk of breast cancer. In this study, we studied the association of breast cancer and the trinucleotide repeat polymorphism (CAG)n in exon 1 of the AR gene in 202 patients with breast cancer and 183 healthy controls from our hospital (Yinchuan, China). Repeat lengths were determined by fluorescent DNA fragment analysis using the ABI GeneScan software and DNA sequencing.

Subscribe to Androgen receptor