Androgen receptor

Androgen receptor (CAG)n polymorphisms and breast cancer risk in a Han Chinese population

J. Dang, Peng, L., Zhong, H. J., and Huo, Z. H., Androgen receptor (CAG)n polymorphisms and breast cancer risk in a Han Chinese population, vol. 14, pp. 10258-10266, 2015.

The androgen receptor (AR) is involved in the differentiation and growth of breast cancer. Genetic markers in the AR gene have a plausible role in modulating the risk of breast cancer. In this study, we studied the association of breast cancer and the trinucleotide repeat polymorphism (CAG)n in exon 1 of the AR gene in 202 patients with breast cancer and 183 healthy controls from our hospital (Yinchuan, China). Repeat lengths were determined by fluorescent DNA fragment analysis using the ABI GeneScan software and DNA sequencing.

Increased androgen receptor messenger RNA in frontal-parietal hair follicles of women with androgenetic alopecia

F. Richeti, Kochi, C., Rocha, M. N., C. Corrêa, S. ’A., Lazzarini, R., Guazzelli, R. M., Mendonça, R. F., Melo, M. R., and Longui, C. A., Increased androgen receptor messenger RNA in frontal-parietal hair follicles of women with androgenetic alopecia, vol. 12, pp. 1834-1840, 2013.

Normal testosterone levels are frequently observed in women with androgenetic alopecia (AGA), suggesting the involvement of androgen sensitivity in this condition. Androgen sensitivity is related to androgen receptor (AR) messenger RNA (mRNA) production in hair follicles and is negatively related to the number of CAG repeats present in exon 1 of the AR gene. The aim of this study was to compare AR expression in AGA women with normal controls and to correlate this expression with the number of CAG repeats.

Association between male infertility and androgen receptor mutations in Brazilian patients

C. O. A. Melo, Danin, A. R., Silva, D. M., Tacon, J. A., Moura, K. K. V. O., Costa, E. O. A., and da Cruz, A. D., Association between male infertility and androgen receptor mutations in Brazilian patients, vol. 9, pp. 128-133, 2010.

The androgen receptor is encoded by a single-copy gene located in the long arm of the X chromosome (Xq11-12); it consists of eight exons and encodes an intracellular transcription factor that belongs to the steroid/nuclear receptor superfamily. Disturbances in the function of the androgen receptor can lead to several forms of male pseudohermaphroditism, such as androgen insensitivity syndrome, which can lead to infertility. Infertility affects around 20% of couples, and in half of the cases it is a male problem.

Size of the exon 1-CAG repeats of the androgen receptor gene employed as a molecular marker in the diagnosis of Turner syndrome in girls with short stature

C. C. Figueiredo, Kochi, C., Longui, C. A., Rocha, M. N., Richeti, F., Evangelista, N. M. A., Calliari, L. E. P., and Monte, O., Size of the exon 1-CAG repeats of the androgen receptor gene employed as a molecular marker in the diagnosis of Turner syndrome in girls with short stature, vol. 7, pp. 43-49, 2008.

Turner syndrome (TS) is one of the most common chromosomal abnormalities among girls. Complete monosomy of X chromosome is responsible for almost 50% of all cases of TS, and mosaicism and X anomaly are detected in the other half. It has already been demonstrated that early diagnosis of these children allows appropriate growth hormone treatment with better final height prognosis and introduction of estrogen at an ideal chronological age.

Absence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a Brazilian population

W. E. J. C. Mesquita, Approbato, M. S., Moura, K. K. V. O., and Jesuíno, R. S. A., Absence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a Brazilian population, vol. 8. pp. 1423-1426, 2009.

The androgen receptor (AR) is a protein encoded by the AR gene, which when mutated may affect spermatogenesis, the process in which spermatozoa are produced; thus, AR mutations could lead to male infertility. We examined exon 1 of the AR gene in men with idiopathic infertility. Blood or semen samples from 111 infertile, oligozoospermic (N = 31), asthenozoospermic (N = 23), teratozoospermic (N = 33), and azoospermic (N = 24) men were analyzed. The extracted DNA was amplified for the exon 1 region of the AR gene.

A three-step molecular protocol employing DNA obtained from dried blood spots for neonatal screening for 45,X Turner syndrome

M. Neves Rocha, Melo, M. Rezende, Longui, C. Alberto, de Oliveira, D. Vilariço, Figueiredo, C. Costa, and Pacchi, P. Roberto, A three-step molecular protocol employing DNA obtained from dried blood spots for neonatal screening for 45,X Turner syndrome, vol. 4, pp. 749-754, 2005.

Turner syndrome (TS) is one of the most common human chromosomal abnormalities; it is characterized by the presence of one normal X chromosome and the complete or partial loss of the second X chromosome. The early recognition of TS patients allows for adequate therapy for short stature and pubertal sex steroid substitution. We developed a cost-effective molecular diagnostic tool that can be used to identify 45,X TS patients from dried blood spots, for possible use in neonatal screening for TS.

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