Amyotrophic lateral sclerosis

Genome-wide pathway analysis in amyotrophic lateral sclerosis

Y. H. Lee and Song, G. G., Genome-wide pathway analysis in amyotrophic lateral sclerosis, vol. 14, pp. 6429-6438, 2015.

The aims of this study were to identify candidate single-nucleotide polymorphisms (SNPs) and mechanisms of amyotrophic lateral sclerosis (ALS) and to generate SNP-to-gene-to-pathway hypotheses. An ALS genome-wide association study (GWAS) dataset that included 483,051 SNPs in 276 patients with ALS and 271 controls of European descent was used in this study. Identify Candidate Causal SNPs and Pathway (ICSNPathway) analysis was applied to the GWAS dataset. ICSNPathway analysis identified 19 candidate SNPs, 8 genes, and 9 pathways, which provided 8 hypothetical biological mechanisms.

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