AMPD1

Genetic evaluation of AMPD1, CPT2, and PGYM metabolic enzymes in patients with chronic fatigue syndrome

P. E. Maltese, Venturini, L., Poplavskaya, E., Bertelli, M., Cecchin, S., Granato, M., Nikulina, S. Y., Salmina, A., Aksyutina, N., Capelli, E., Ricevuti, G., Lorusso, L., Maltese, P. E., Venturini, L., Poplavskaya, E., Bertelli, M., Cecchin, S., Granato, M., Nikulina, S. Y., Salmina, A., Aksyutina, N., Capelli, E., Ricevuti, G., and Lorusso, L., Genetic evaluation of AMPD1, CPT2, and PGYM metabolic enzymes in patients with chronic fatigue syndrome, vol. 15, p. -, 2016.

Chronic fatigue syndrome (CFS) is a disease that can seriously impair one’s quality of life; patients complain of excessive fatigue and myalgia following physical exertion. This disease may be associated with abnormalities in genes affecting exercise tolerance and physical performance. Adenosine monophosphate deaminase (AMPD1), carnitine palmitoyltransferase II (CPT2), and the muscle isoform of glycogen phosphorylase (PYGM) genes provide instructions for producing enzymes that play major roles in energy production during work.

Association between the C34T polymorphism of the AMPD1 gene and essential hypertension in Malaysian patients

R. Nemati, Lu, J., Ramachandran, V., Etemad, A., Heidari, M., Yahya, M. J., Roozafzoon, R., Ismail, P., Nemati, R., Lu, J., Ramachandran, V., Etemad, A., Heidari, M., Yahya, M. J., Roozafzoon, R., and Ismail, P., Association between the C34T polymorphism of the AMPD1 gene and essential hypertension in Malaysian patients, vol. 15, p. -, 2016.

The aim of this study was to determine whether C34T, a common polymorphism of the adenosine monophosphate deaminase 1 gene (AMPD1), is associated with essential hypertension (EH). We hypothesize that C34T is associated with the development of EH. A case-control design was used for this study. The DNA was extracted using a commercial kit from the whole blood of 200 patients with hypertension and 200 subjects without hypertension from selected Malaysian ethnicities (Malays, Chinese, and Indians).

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