AMP-activated protein kinase

AMP-activated protein kinase regulates autophagic protection against cisplatin-induced tissue injury in the kidney

L. Wei, Chen, W., Zou, Y., Huang, H., Pan, B., Jin, S., Huang, R., Nie, S., and Kong, G., AMP-activated protein kinase regulates autophagic protection against cisplatin-induced tissue injury in the kidney, vol. 14, pp. 12006-12015, 2015.

Although the nephrotoxicity of cisplatin has been well documented as a major side effect of chemotherapy, the exact mechanism by which prosurvival and apoptotic pathways interplay to determine renal pathology remains elusive. Recent studies suggested that autophagy might serve as an adaptive mechanism to promote cell survival during acute kidney injury (AKI). We have used AKI as a disease model to investigate the mechanism regulating the cytoprotective role of autophagy in cisplatin-induced tissue damage.

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