Ames/Salmonella test

Genotoxic evaluation of the organophosphorous pesticide temephos

C. Alessandra Aiub, Aiub, C. Alessandra, Coelho, E. Cristina A., Sodré, E., Pinto, L. Felipe Rib, and Felzenszwalb, I., Genotoxic evaluation of the organophosphorous pesticide temephos, vol. 1, pp. 159-166, 2002.

The chemical compound temephos (0,0,0',0'-tetrametyl-0,0'-thiodi-p-phenylene phosphorothioate) is an organophosphorous pesticide that has been used in Brazil since 1967 in control campaigns against the mosquito Aedes aegypti, the vector of dengue and yellow fever. We used single cell gel electrophoresis (SCGE), SOS/umu and Ames/Salmonella assays to test the toxicity and mutagenicity of temephos. Temephos was genotoxic in the SCGE assay, inducing severe DNA lesions (type IV lesions) at doses above 1.34 µM.

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