Alzheimer’s disease

Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease

L. Ma, Lu, Z. N., Ma, L., and Lu, Z. N., “Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease”, vol. 15, p. -, 2016.

In the present study, we investigated the association between ADH1B rs1229984 and ALDH2 rs671 polymorphisms and the development of Alzheimer’s disease in a Chinese population. Genotyping of the ADH1B rs1229984 and ALDH2 rs671 polymorphisms was carried out by polymerase chain reaction-restriction fragment length polymorphism. Logistic regression analyses revealed that the AA genotype of ADH1B rs1229984 was associated with an increased risk of Alzheimer’s disease (OR = 2.54, 95%CI = 1.19-5.41).

Applying the Fisher score to identify Alzheimer's disease-related genes

J. Yang, Liu, Y. L., Feng, C. S., Zhu, G. Q., Yang, J., Liu, Y. L., Feng, C. S., and Zhu, G. Q., “Applying the Fisher score to identify Alzheimer's disease-related genes”, vol. 15, p. -, 2016.

Biologists and scientists can use the data from Alzheimer's disease (AD) gene expression microarrays to mine AD disease-related genes. Because of disadvantages such as small sample sizes, high dimensionality, and a high level of noise, it is difficult to obtain accurate and meaningful biological information from gene expression profiles. In this paper, we present a novel approach for utilizing AD microarray data to identify the morbigenous genes. The Fisher score, a classical feature selection method, is utilized to evaluate the importance of each gene.

Distribution of LIM domain kinase 1 in the olfactory bulb, cerebral cortex, hippocampus, and cerebellum of the App/PS+/- mice

L. An, Liu, J., Li, W. W., Shi, Y. J., Lin, X. H., Yu, D. M., Deng, J. B., and Ren, X. Q., “Distribution of LIM domain kinase 1 in the olfactory bulb, cerebral cortex, hippocampus, and cerebellum of the App/PS+/- mice”, vol. 14, pp. 17244-17251, 2015.

LIM domain kinase 1 (LIMK1), an actin-binding kinase, can phosphorylate and inactivate its substrates, and can regulate long-term memory and synaptic plasticity. Both β-amyloid precursor protein (App) and presenilin (PS) are functional degeneration factors during early neuronal development, and are considered as potential factors that contribute to the development of Alzheimer’s disease (AD). However, hardly any information is available about the distribution and expression of LIMK1.

Expression of human amyloid precursor protein in Drosophila melanogaster nerve cells causes a decrease in presynaptic gene mRNA levels

D. I. Rodin, Schwarzman, A. L., and Sarantseva, S. V., “Expression of human amyloid precursor protein in Drosophila melanogaster nerve cells causes a decrease in presynaptic gene mRNA levels”, vol. 14, pp. 9225-9232, 2015.

Amyloid precursor protein (APP) is a key player in Alzheimer’s disease. The proteolytic cleavage of APP results in various short peptide fragments including the toxic amyloid-beta peptide, which is a main component of senile plaques. However, the functions of APP and its processed fragments are not yet well understood.

Effect of phosphatidylserine on memory in patients and rats with Alzheimer’s disease

Y. Y. Zhang, Yang, L. Q., and Guo, L. M., “Effect of phosphatidylserine on memory in patients and rats with Alzheimer’s disease”, vol. 14, pp. 9325-9333, 2015.

The aim of this study was to investigate the effect of phosphatidylserine (PS) on memory of patients and rats with Alzheimer’s disease (AD). In total, 57 AD patients were recruited from our hospital, and were divided into two groups: 25 in the control group and 32 in the observation group. Next, 300 mg/d of PS was given to the rats in the observation group for 12 continuous weeks based on the control group. AD rats were divided into three groups: control group, PS 30 mg/kg group, and PS 15 mg/kg group.

Estrogen receptor 1 PvuII and XbaI polymorphisms and susceptibility to Alzheimer’s disease: a meta-analysis

Y. H. Lee and Song, G. G., “Estrogen receptor 1 PvuII and XbaI polymorphisms and susceptibility to Alzheimer’s disease: a meta-analysis”, vol. 14, pp. 9361-9369, 2015.

The aim of this study was to explore whether estrogen receptor 1 (ESR1) PvuII and XbaI polymorphisms are associated with susceptibility to Alzheimer’s disease (AD). We conducted a meta-analysis of the associations between AD and ESR1 PvuII and XbaI polymorphisms as well as haplotypes of the ESR1 PvuII and XbaI polymorphisms.

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