Alzheimer’s disease

Applying the Fisher score to identify Alzheimer's disease-related genes

J. Yang, Liu, Y. L., Feng, C. S., Zhu, G. Q., Yang, J., Liu, Y. L., Feng, C. S., and Zhu, G. Q., Applying the Fisher score to identify Alzheimer's disease-related genes, vol. 15, p. -, 2016.

Biologists and scientists can use the data from Alzheimer's disease (AD) gene expression microarrays to mine AD disease-related genes. Because of disadvantages such as small sample sizes, high dimensionality, and a high level of noise, it is difficult to obtain accurate and meaningful biological information from gene expression profiles. In this paper, we present a novel approach for utilizing AD microarray data to identify the morbigenous genes. The Fisher score, a classical feature selection method, is utilized to evaluate the importance of each gene.

Distribution of LIM domain kinase 1 in the olfactory bulb, cerebral cortex, hippocampus, and cerebellum of the App/PS+/- mice

L. An, Liu, J., Li, W. W., Shi, Y. J., Lin, X. H., Yu, D. M., Deng, J. B., and Ren, X. Q., Distribution of LIM domain kinase 1 in the olfactory bulb, cerebral cortex, hippocampus, and cerebellum of the App/PS+/- mice, vol. 14, pp. 17244-17251, 2015.

LIM domain kinase 1 (LIMK1), an actin-binding kinase, can phosphorylate and inactivate its substrates, and can regulate long-term memory and synaptic plasticity. Both β-amyloid precursor protein (App) and presenilin (PS) are functional degeneration factors during early neuronal development, and are considered as potential factors that contribute to the development of Alzheimer’s disease (AD). However, hardly any information is available about the distribution and expression of LIMK1.

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