Alzheimer’s disease

Expression of human amyloid precursor protein in Drosophila melanogaster nerve cells causes a decrease in presynaptic gene mRNA levels

D. I. Rodin, Schwarzman, A. L., and Sarantseva, S. V., “Expression of human amyloid precursor protein in Drosophila melanogaster nerve cells causes a decrease in presynaptic gene mRNA levels”, vol. 14, pp. 9225-9232, 2015.

Amyloid precursor protein (APP) is a key player in Alzheimer’s disease. The proteolytic cleavage of APP results in various short peptide fragments including the toxic amyloid-beta peptide, which is a main component of senile plaques. However, the functions of APP and its processed fragments are not yet well understood.

Effect of phosphatidylserine on memory in patients and rats with Alzheimer’s disease

Y. Y. Zhang, Yang, L. Q., and Guo, L. M., “Effect of phosphatidylserine on memory in patients and rats with Alzheimer’s disease”, vol. 14, pp. 9325-9333, 2015.

The aim of this study was to investigate the effect of phosphatidylserine (PS) on memory of patients and rats with Alzheimer’s disease (AD). In total, 57 AD patients were recruited from our hospital, and were divided into two groups: 25 in the control group and 32 in the observation group. Next, 300 mg/d of PS was given to the rats in the observation group for 12 continuous weeks based on the control group. AD rats were divided into three groups: control group, PS 30 mg/kg group, and PS 15 mg/kg group.

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