Allium cepa

Cytotoxicity and mutagenicity of fluoxetine hydrochloride (Prozac), with or without vitamins A and C, in plant and animal model systems

E. Düsman, Almeida, I. V., Mariucci, R. G., Mantovani, M. S., and Vicentini, V. E. P., Cytotoxicity and mutagenicity of fluoxetine hydrochloride (Prozac), with or without vitamins A and C, in plant and animal model systems, vol. 13, pp. 578-589, 2014.

Fluoxetine, commonly known as Prozac, is the first representative of the so-called new generation of antidepressants that promise efficacy, with few side effects, against deep depression, nervous bulimia, and anxiety. As there is a growing number of people suffering from anxiety and depression; consequently, the use of fluoxetine is also increasing. Verifying absence of drug effects such as cytotoxicity or mutagenicity is of great importance. Certain vitamins, such as vitamin A (retinol, retinoids) and vitamin C (ascorbic acid) protect and are extremely active against mutagens.

Increasing mutagenicity of São Gonçalo Channel waters based on the Allium cepa test

T. S. Paiva, Garcias, G. L., and Martino-Roth, M. G., Increasing mutagenicity of São Gonçalo Channel waters based on the Allium cepa test, vol. 8, pp. 299-309, 2009.

The São Gonçalo Channel is of great importance to the conservation of local biodiversity; it also is a water supply source of the city of Pelotas, Brazil, and the surrounding region. We examined the mutagenic activity of its waters. The following items were seasonally investigated in Allium cepa root radicular meristem cells: mitotic index, mitotic anomalies, interphase anomalies, and total anomalies. Water samples were collected from four different stations, Lock Dam, Santa Bárbara Channel, Pelotas Creek, and Barra do Laranjal. A drinking water negative control was used.

Mutagenic potential of water from Pelotas Creek in Rio Grande do Sul, Brazil

T. C. O. Santos, Maciel, L. F., Leal, K. S., Bender, A. E. N., Paiva, T. S., Garcias, G. L., and Martino-Roth, M. G., Mutagenic potential of water from Pelotas Creek in Rio Grande do Sul, Brazil, vol. 8, pp. 1057-1066, 2009.

Water resource degradation is one of mankind’s greatest worries, as it causes direct and indirect damage to the associated biota. We initiated a water monitoring study in Pelotas Creek in 2003 in order to assess the mutagenic effect of the creek’s waters. Allium cepa cells exposed to water samples and a chronically exposed macrophyte were analyzed, through evaluation of the mitotic index, mitotic anomalies, interphase anomalies, and total anomalies.

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