All-trans retinoic acid

Role of Nrf2 signal pathway in rats with deep hypothermia ischemia/reperfusion injury undergoing remote postconditioning

Z. Y. Wu, Wang, Z. W., Hu, R., Zhou, Z., Li, L. C., and Mao, Z. F., Role of Nrf2 signal pathway in rats with deep hypothermia ischemia/reperfusion injury undergoing remote postconditioning, vol. 14, pp. 492-499, 2015.

We investigated the protective effects of remote postconditioning (RPC) in the lungs of rats with deep hypothermia ischemia/reperfusion (I/R) injury and the role of nuclear factor E2-related factor 2 (Nrf2) signaling in this process. Forty-nine rats were randomly divided into a sham control group, deep hypothermia I/R group, RPC group, I/R+all-trans retinoic acid (ATRA) group, I/R+RPC+ATRA group, I/R+tert-butylhydroquinone (tBHQ) group, and I/R+RPC+tBHQ group.

WY14643 combined with all-trans retinoic acid acts via p38 MAPK to induce “browning” of white adipocytes in mice

J. Wang, Sun, G. J., Ding, J., Zhang, J. X., Cui, Y., Li, H. R., and Wang, S. J., WY14643 combined with all-trans retinoic acid acts via p38 MAPK to induce “browning” of white adipocytes in mice, vol. 14, pp. 6978-6984, 2015.

The ability of mammals to resist body fat accumulation is linked to their ability to expand the number of “brown adipocytes” within white fat depots. All-trans retinoic acid (t-RA) and peroxi­some proliferator-activated receptor-α (PPARα) have been implicated in “browning-like” or “browning” programs, respectively. However, a PPARα-agonist (WY14643) failed to regulate the expression of the uncoupling protein 1(UCP1) gene unless combined with retinoic acid.

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