Age-related macular degeneration

Clinical study of the correlation between complement factor H polymorphism and age-related macular degeneration

H. T. Dong, Zhang, J. X., Li, Q. M., Li, F. Z., Dong, H. T., Zhang, J. X., Li, Q. M., and Li, F. Z., “Clinical study of the correlation between complement factor H polymorphism and age-related macular degeneration”, vol. 15, p. -, 2016.

This study aimed to investigate the correlation between age-related macular degeneration (AMD) of the liver-kidney yin-deficiency type and complement factor H (CFH) polymorphism, and to determine whether the C allele of the T1277C (Y402H) variant is a risk factor for this condition. We performed a case-control investigation of 60 patients with liver-kidney yin-deficiency AMD and 60 normal control subjects. Peripheral blood was collected from each participant for DNA extraction.

Genome-wide analysis of single nucleotide polymorphisms in patients with atrophic age-related macular degeneration in oldest old Han Chinese

T. Q. Zhou, Guan, H. J., and Hu, J. Y., “Genome-wide analysis of single nucleotide polymorphisms in patients with atrophic age-related macular degeneration in oldest old Han Chinese”, vol. 14, pp. 17432-17438, 2015.

The aim of this study was to identify disease-associated loci in oldest old Han Chinese with atrophic age-related macular degeneration (AMD). This genome-wide association study (GWAS) only included oldest old (≥95 years old) subjects in Rugao County, China. Thirty atrophic AMD patients and 47 age-matched non-AMD controls were enrolled. The study subjects underwent a complete ophthalmic examination. Genomic DNA was extracted from peripheral blood samples. Single nucleotide polymorphisms (SNPs) were scanned by Genome-Wide Human Mapping SNP 6.0 Arrays and GeneChip Scanner 3000 7G.

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