Adefovir dipivoxil

Curative effect of combined lamivudine, adefovir dipivoxil, and stem cell transplantation on decompensated hepatitis B cirrhosis

L. Liu, Yan, Y., Zhou, J., Huang, L. W., He, C. P., Ling, K., Zhou, H. C., Wen, Q. M., and Wang, X. M., Curative effect of combined lamivudine, adefovir dipivoxil, and stem cell transplantation on decompensated hepatitis B cirrhosis, vol. 13, pp. 9336-9342, 2014.

This study assessed the clinical efficacy of lamivudine and adefovir dipivoxil combined with autologous bone marrow stem cell transplantation as treatment for patients with hepatitis B and decompensated liver cirrhosis. In total, 77 patients with hepatitis B and decompensated liver cirrhosis were randomly divided into two groups.

An improved reverse dot hybridization for simple and rapid detection of adefovir dipivoxil-resistant hepatitis B virus

Y. Hu, Zhang, W. L., Xie, S. L., Zhao, Y., Hu, J. L., Cai, X. F., Lai, G. Q., and Huang, A. L., An improved reverse dot hybridization for simple and rapid detection of adefovir dipivoxil-resistant hepatitis B virus, vol. 11, pp. 53-60, 2012.

Early detection of adefovir dipivoxil-resistant mutants during long-term treatment of chronic hepatitis B virus (HBV) infection with this drug is of great clinical importance. We developed an improved reverse dot hybridization test for simple and rapid detection of the rtA181V/T and rtN236T mutations associated with adefovir dipivoxil resistance in chronic hepatitis B patients. Probes were designed for genotypes B, C, and D of this resistance characteristic; a total of 70 clinical samples were analyzed with this improved reverse dot hybridization assay.

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