Addiction

The role of α-satellite DNA and heterochromatin polymorphism in leukemia patients and illicit drug addicts

A. Movafagh, Mortazavi-Tabatabaei, S. A., and Kolahi, A. A., The role of α-satellite DNA and heterochromatin polymorphism in leukemia patients and illicit drug addicts, vol. 10, pp. 3999-4005, 2011.

Heterochromatin is considered to play a role in protecting the genome against mutagens. Changes in the quantity and proportion of different types of satellite DNA could increase genetic susceptibility in individuals with heterochromatic variations; they cause chromosome instability and predispose patients to malignancies. We evaluated the heterochromatin associated with chromosomes in 50 leukemia patients, 93 drug addicts and 93 healthy controls from Tehran, Iran.

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