The role of α-satellite DNA and heterochromatin polymorphism in leukemia patients and illicit drug addicts
“The role of α-satellite DNA and heterochromatin polymorphism in leukemia patients and illicit drug addicts”, vol. 10, pp. 3999-4005, 2011.
, Heterochromatin is considered to play a role in protecting the genome against mutagens. Changes in the quantity and proportion of different types of satellite DNA could increase genetic susceptibility in individuals with heterochromatic variations; they cause chromosome instability and predispose patients to malignancies. We evaluated the heterochromatin associated with chromosomes in 50 leukemia patients, 93 drug addicts and 93 healthy controls from Tehran, Iran.