Acute promyelocytic leukemia

Identification of PML/RARα fusion gene transcripts that showed no t(15;17) with conventional karyotyping and fluorescent in situ hybridization

A. Choughule, Polampalli, S., Amre, P., Shinde, S., Banavali, S., Prabhash, K., Nair, R., Subramanian, P. G., Gujral, S., and Parikh, P. M., Identification of PML/RARα fusion gene transcripts that showed no t(15;17) with conventional karyotyping and fluorescent in situ hybridization, vol. 8, pp. 1-7, 2009.

Acute promyelocytic leukemia (APL) is characterized by a reciprocal translocation, t(15;17)(q22;q11-21), resulting in the fusion of the promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARα) genes. Using conventional cytogenetic methods, these translocations are normally detected in about 70-90% of patients; most negative results are due to technical problems or cryptic variants.

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