Acrylonitrile

Effects of acrylonitrile on the pathological morphology and apoptosis of neurons in rats

C. Z. Li, Tse, L. A., Zhou, Y. L., Fan, W., Li, M., Yu, I. T. S., and Jin, T. Y., Effects of acrylonitrile on the pathological morphology and apoptosis of neurons in rats, vol. 13, pp. 5795-5802, 2014.

This study aimed to evaluate the effects of acrylonitrile (ACN) on neuronal morphology and apoptosis in rats. An ACN solution was administered to Wistar rats by gavage at doses of 0, 5, 10, or 20 mg/kg, 5 days a week for 13 weeks. The morphology of neurons and the presence of apoptosis was examined by light and electron microscope, DNA electrophoresis, immunohistochemistry, and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling.

Effects of acrylonitrile on lymphocyte lipid rafts and RAS/RAF/MAPK/ERK signaling pathways

X. J. Li, Li, B., Huang, J. S., Shi, J. M., Wang, P., Fan, W., and Zhou, Y. L., Effects of acrylonitrile on lymphocyte lipid rafts and RAS/RAF/MAPK/ERK signaling pathways, vol. 13, pp. 7747-7756, 2014.

Acrylonitrile (ACN) is a widely used chemical in the production of plastics, resins, nitriles, acrylic fibers, and synthetic rubber. Previous epidemiological investigations and animal studies have confirmed that ACN affects the lymphocytes and spleen. However, the immune toxicity mechanism is unknown. Lipid rafts are cell membrane structures that are rich in cholesterol and involved in cell signal transduction. The B cell lymophoma-10 (Bcl10) protein is a joint protein that is important in lymphocyte development and signal pathways.

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