ACE I/D polymorphism

Molecular thrombophilic profile in Mexican patients with idiopathic recurrent pregnancy loss

J. J. López-Jiménez, Porras-Dorantes, Á., Juárez-Vázquez, C. I., García-Ortiz, J. E., Fuentes-Chávez, C. A., Lara-Navarro, I. J., Jaloma-Cruz, A. R., López-Jiménez, J. J., Porras-Dorantes, Á., Juárez-Vázquez, C. I., García-Ortiz, J. E., Fuentes-Chávez, C. A., Lara-Navarro, I. J., and Jaloma-Cruz, A. R., Molecular thrombophilic profile in Mexican patients with idiopathic recurrent pregnancy loss, vol. 15, p. -, 2016.

Idiopathic recurrent pregnancy loss (IRPL) is defined by three or more consecutive miscarriages occurring before the twentieth week of gestation as a result of unidentified etiological factors. The results of previous studies have indicated that prothrombotic factors play a pathogenic role in early and late pregnancy. This study aimed to identify inherited prothrombotic and hypofibrinolytic risk factors in Mexican-Mestizo patients with IRPL.

Meta-analysis demonstrates lack of association between the ACE gene I/D polymorphism and obstructive sleep apnea-hypopnea syndrome occurrence and severity

Y. Feng, Ri, J., Wan, H. Y., Shi, G. C., Li, Q. Y., and Fan, L., Meta-analysis demonstrates lack of association between the ACE gene I/D polymorphism and obstructive sleep apnea-hypopnea syndrome occurrence and severity, vol. 12, pp. 74-84, 2013.

Published data on a possible association between the angiotensin-converting enzyme (ACE) gene I/D polymorphism and obstructive sleep apnea-hypopnea syndrome (OSAHS) occurrence and its severity risk are inconclusive. We performed a meta-analysis of case-control studies published in English or Chinese. Thirteen studies, totaling 1361 cases and 1373 controls, were investigated for association of the ACE I/D polymorphism with OSAHS. We also made a study of ACE I/D with OSAHS severity risk, including 879 mild/moderate OSAHS patients and 357 severe OSAHS patients.

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