A1298C polymorphism

MTHFR A1298C polymorphism and ovarian cancer risk: a meta-analysis

X. Y. Shi and Shen, Q., MTHFR A1298C polymorphism and ovarian cancer risk: a meta-analysis, vol. 14, pp. 8211-8218, 2015.

Numerous studies have evaluated the association between the MTHFR A1298C polymorphism and ovarian cancer risk. However, the specific association is still controversial. Therefore, we performed the present meta-analysis. A systematic literature search of PubMed and Embase databases was undertaken in August 2014, and the reference lists of articles were retrieved. ORs with their 95%CI were calculated to evaluate the strength of the association. Meta-analysis was performed using the STATA version 12.0 software package and publication bias was investigated by Begg’s funnel plot.

Ethnic variation of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate-reductase (MTHFR) gene in southwestern Mexico

V. Antonio-Véjar, del Moral-Hernández, O., Alarcón-Romero, L. C., Flores-Alfaro, E., Leyva-Vázquez, M. A., Hernández-Sotelo, D., and Illades-Aguiar, B., Ethnic variation of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate-reductase (MTHFR) gene in southwestern Mexico, vol. 13, pp. 7950-7957, 2014.

In this study, we examined the distribution of genotype and allele frequencies of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate-reductase gene (MTHFR) in two ethnic groups in the State of Guerrero, Mexico, which were compared with those of the Mestizo population of the region. A comparative study was conducted on 455 women from two ethnic groups and a group of Mestizo women of the State of Guerrero, Mexico: 135 Nahuas, 124 Mixtecas, and 196 Mestizas.

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