5-Azacytidine

5-Azacytidine suppresses the proliferation of pancreatic cancer cells by inhibiting the Wnt/β-catenin signaling pathway

H. Zhang, Zhou, W. C., Li, X., Meng, W. B., Zhang, L., Zhu, X. L., Zhu, K. X., Bai, Z. T., Yan, J., Liu, T., Xu, X. C., and Li, Y. M., 5-Azacytidine suppresses the proliferation of pancreatic cancer cells by inhibiting the Wnt/β-catenin signaling pathway, vol. 13, pp. 5064-5072, 2014.

5-Azacytidine has been shown to be an effective anti-pancreatic cancer drug, but the mechanism remains unknown. In the current study, we explored the effect of 5-azacytidine on abnormal activation of the Wnt-β-catenin signaling pathway in pancreatic cancer cells. The human pancreatic cancer cell line Bxpc-3 was treated with different concentrations of 5-azacytidine for various times. The proliferation and early apoptosis of the cells were evaluated using the CCK8 method and flow cytometry, respectively.

Gametocidal chromosomes enhancing chromosome aberration in common wheat induced by 5-azacytidine

W. - Y. Su, Cong, W. - W., Shu, Y. - J., Wang, D., Xu, G. - H., and Guo, C. - H., Gametocidal chromosomes enhancing chromosome aberration in common wheat induced by 5-azacytidine, vol. 12, pp. 2227-2233, 2013.

The gametocidal (Gc) chromosome from Aegilops spp induces chromosome mutation, which is introduced into common wheat as a tool of chromosome manipulation for genetic improve­ment. The Gc chromosome functions similar to a restriction-modifi­cation system in bacteria, in which DNA methylation is an important regulator. We treated root tips of wheat carrying Gc chromosomes with the hypomethylation agent 5-azacytidine; chromosome break­age and micronuclei were observed in these root tips.

Subscribe to 5-Azacytidine