The T-allele of the SMARCA4 gene has an apparent protective effect against high levels of total and LDL cholesterol
The main polymorphisms linked to dyslipidemia include those of the SMARCA4 gene. We evaluated the association between lipidic profile and SMARCA4 gene polymorphism in 200 military police officers. Real time PCR was used to identify SMARCA4 gene polymorphisms. Among the subjects, 116 had dyslipidemia (case group), of which 94% were males, and 84 presented no dyslipidemia (control group), of which 92% were males. For the SMARCA4 gene polymorphism, 66.4% (77/116) presented the GG genotype, 31.0% (36/116), GT and 2.6% (3/116) TT. Individuals with GG, GT and TT genotypes had LDL cholesterol levels higher than 160 mg/dL, respectively, at frequencies of 28.6, 11.1 and 0%, while total cholesterol higher than 190 mg/dL, was at frequencies of 74.0, 58.3 and 33.3%. Logistic regression analysis to determine the p-values, considering the T allele as dominant, suggested that this allele has the ability to protect the individual from high cholesterol levels (OR, 0.488; 95% CI 0.27 - 0.88; P = 0.0163) and high LDL cholesterol levels (OR 0.277; 95% CI 0.09 - 0.84; P = 0.0230). Absence of the T allele was associated with increased susceptibility to dyslipidemia. Individuals who are homozygous or heterozygous for the T allele are approximately two times more likely to have normal cholesterol levels, and about 3.5 times more likely to have normal LDL levels.