Research Article

miR-367 promotes uveal melanoma cell proliferation and migration by regulating PTEN.

Published: August 17, 2017
Genet. Mol. Res. 16(3): DOI: https://doi.org/10.4238/gmr16039067

Abstract

We aimed to investigate the biological role of miR-367 in uveal melanoma cell growth and migration, and the underlying mechanism responsible. Quantitative real-time polymerase chain reaction was performed to evaluate miR-367 expression in uveal melanoma tissue samples and cell lines. A miR-367 mimic, miR-367 inhibitor, and negative control oligonucleotide were transfected into these cells to investigate the function of this microRNA. In addition, the role of PTEN in miR-367-mediated uveal melanoma cell growth and migration was evaluated. miR-367 was significantly upregulated in uveal melanoma cells and tissue samples (both P

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