Research Article

Improvement of Exercise Intervention on Vascular Endothelial Functions during Prediabetes Mellitus

Published: November 29, 2017
Genet. Mol. Res. 16(4): gmr16039830 DOI: 10.4238/gmr16039830


Prediabetes is considered to be an at a risk state, with
an annualized 5-10% conversion rate of diabetes and the similiar
proportion converting back to normoglycaemia. The global
incidence of prediabetes is increasing and will reach to 471 million
patients in 2030. The elevation of blood sugar is a continuum and
hence prediabetes cannot be considered an entirely benign status and
present insulin resistance (IR) and β-cell dysfunction, so that the
development of prediabetic complications and vascular endothelial
dysfunction. Therefore, it is crucial to early recognition and
treatment of prediabetic individuals. For prediabetic individuals,
lifestyle modification is the cornerstone of diabetes prevention with
evidence of a 40-70% relative risk reduction. In the review, we
include the possible mechanism of IR-induced vascular endothelial
dysfunction, and exercise intervention improving the vascular
endothelial dysfunction. These results showed clearly positive
effects of physical exercise intervention and provided a direct
clinical evidence of the effectiveness of this approach for preventing
early diabetes