Research Article

Association between interleukin-17 gene polymorphisms and the risk of laryngeal cancer in a Chinese population.

Published: March 30, 2017
Genet. Mol. Res. 16(1): gmr16019076 DOI: https://doi.org/10.4238/gmr16019076
Cite this Article:
(2017). Association between interleukin-17 gene polymorphisms and the risk of laryngeal cancer in a Chinese population.. Genet. Mol. Res. 16(1): gmr16019076. https://doi.org/10.4238/gmr16019076
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Abstract

IL-17 is associated with the occurrence and development of laryngeal cancer. However, no study has reported the association between IL-17 polymorphisms and laryngeal cancer susceptibility. Therefore, we analyzed the association of three polymorphism loci (rs2275913, 197 G/A; rs3748067, 383 A/G; and rs763780, 7488 T/C) of IL-17A and IL-17F with laryngeal cancer in the Chinese population. A case-control study was performed with 325 patients and 325 controls. Polymorphisms were detected by polymerase chain reaction and sequencing methods. SPSS17.0 software was used for statistical analysis. Allele and genotype frequencies of IL-17A rs2275913 were significantly different between patients and controls (P

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