Research Article

β3-adrenergic receptor polymorphism is related to cardiometabolic risk factors in obese Brazilian subjects

Published: July 20, 2010
Genet. Mol. Res. 9 (3) : 1392-1397 DOI: https://doi.org/10.4238/vol9-3gmr819
Cite this Article:
(2010). β3-adrenergic receptor polymorphism is related to cardiometabolic risk factors in obese Brazilian subjects. Genet. Mol. Res. 9(3): gmr819. https://doi.org/10.4238/vol9-3gmr819
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Abstract

We determined whether ADRβ3 polymorphism is associated with obesity-related traits in 140 obese patients. Molecular analysis was performed by PCR and RFLP. Individuals carrying the Arg64 allele had a lower waist-to-hip ratio, higher adiponectin and high-density lipoprotein cholesterol levels, and a tendency towards lower blood pressure. In contrast, Trp64/Trp64 carriers were at greater risk for dysmetabolic phenotypes (odds ratio = 2.88, P = 0.03).

We determined whether ADRβ3 polymorphism is associated with obesity-related traits in 140 obese patients. Molecular analysis was performed by PCR and RFLP. Individuals carrying the Arg64 allele had a lower waist-to-hip ratio, higher adiponectin and high-density lipoprotein cholesterol levels, and a tendency towards lower blood pressure. In contrast, Trp64/Trp64 carriers were at greater risk for dysmetabolic phenotypes (odds ratio = 2.88, P = 0.03).