Research Article

CDKAL1 and type 2 diabetes: a global meta-analysis

Published: June 15, 2010
Genet. Mol. Res. 9 (2) : 1109-1120 DOI: https://doi.org/10.4238/vol9-2gmr802
Cite this Article:
(2010). CDKAL1 and type 2 diabetes: a global meta-analysis. Genet. Mol. Res. 9(2): gmr802. https://doi.org/10.4238/vol9-2gmr802
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Abstract

CDKAL1 (cyckin-dependent kinase 5 regulatory subunit-associated protein 1-like 1) has been shown to be associated with type 2 diabetes in various ethnic groups; however, contradictory results have been reported. We performed a comprehensive meta-analysis of 21 studies for rs7756992, 17 studies for rs7754840 and 10 studies for rs10946398 variants of the CDKAL1 gene to evaluate the effect of CDKAL1 on genetic susceptibility for type 2 diabetes. We found a significant association of rs7756992, rs7754840 and rs10946398 in CDKAL1 with type 2 diabetes (odds ratio (OR) = 1.15, 95% confidence interval (CI) = 1.07-1.23, P CDKAL1 polymorphisms and type 2 diabetes, but these associations vary in different ethnic populations.

CDKAL1 (cyckin-dependent kinase 5 regulatory subunit-associated protein 1-like 1) has been shown to be associated with type 2 diabetes in various ethnic groups; however, contradictory results have been reported. We performed a comprehensive meta-analysis of 21 studies for rs7756992, 17 studies for rs7754840 and 10 studies for rs10946398 variants of the CDKAL1 gene to evaluate the effect of CDKAL1 on genetic susceptibility for type 2 diabetes. We found a significant association of rs7756992, rs7754840 and rs10946398 in CDKAL1 with type 2 diabetes (odds ratio (OR) = 1.15, 95% confidence interval (CI) = 1.07-1.23, P CDKAL1 polymorphisms and type 2 diabetes, but these associations vary in different ethnic populations.

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