Research Article

Constructing gene network based on biclusters of expression data

Published: July 14, 2016
Genet. Mol. Res. 15(2): gmr8784 DOI: https://doi.org/10.4238/gmr.15028784
Cite this Article:
F. Liu, L. Yang, Z.Z. Tian, P. Wu, S.L. Sun, F. Liu, L. Yang, Z.Z. Tian, P. Wu, S.L. Sun (2016). Constructing gene network based on biclusters of expression data. Genet. Mol. Res. 15(2): gmr8784. https://doi.org/10.4238/gmr.15028784
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Abstract

Two genes can be co-regulated and possibly have the similar function if they are similarly expressed, which provides a theoretical basis for construction of gene regulatory networks using gene expression data. Herein, a new method of gene regulatory network was constructed based on biclusters in this paper. Given a bicluster, this paper analyzes the correlation between genes in the clusters and then constructs the gene regulatory network by selecting genes with a correlation coefficient.

Two genes can be co-regulated and possibly have the similar function if they are similarly expressed, which provides a theoretical basis for construction of gene regulatory networks using gene expression data. Herein, a new method of gene regulatory network was constructed based on biclusters in this paper. Given a bicluster, this paper analyzes the correlation between genes in the clusters and then constructs the gene regulatory network by selecting genes with a correlation coefficient.

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