Research Article

Hemoglobin (Hb) Val de Marne (Hb Footscray) in Brazil: the first case report

Published: July 14, 2016
Genet. Mol. Res. 15(2): gmr8294 DOI: https://doi.org/10.4238/gmr.15028294
Cite this Article:
J.V. Okumura, E.L.T. Shimauti, D.G.H. Silva, L.S. Torres, E. Belini-Junior, R.G. Oliveira, E.V. Patussi, J.C.M. Herrero, C.R. Bonini-Domingos, J.V. Okumura, E.L.T. Shimauti, D.G.H. Silva, L.S. Torres, E. Belini-Junior, R.G. Oliveira, E.V. Patussi, J.C.M. Herrero, C.R. Bonini-Domingos (2016). Hemoglobin (Hb) Val de Marne (Hb Footscray) in Brazil: the first case report. Genet. Mol. Res. 15(2): gmr8294. https://doi.org/10.4238/gmr.15028294
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Abstract

Hemoglobin (Hb) variants involving alpha-chains are less common in the global population than Hb variants resulting from beta-chain alterations. Generally, alpha-chain Hb variants are caused by point mutations affecting alpha-1 and/or alpha-2 genes of the alpha-globin cluster (HBA1 and HBA2). In Brazil, the most prevalent alpha-chain Hb variant is Hb Hasharon. In this study, we present the first case of an Hb Val de Marne variant in the Americas, specifically in Brazil.

Hemoglobin (Hb) variants involving alpha-chains are less common in the global population than Hb variants resulting from beta-chain alterations. Generally, alpha-chain Hb variants are caused by point mutations affecting alpha-1 and/or alpha-2 genes of the alpha-globin cluster (HBA1 and HBA2). In Brazil, the most prevalent alpha-chain Hb variant is Hb Hasharon. In this study, we present the first case of an Hb Val de Marne variant in the Americas, specifically in Brazil.