Research Article

rs3918242 MMP9 gene polymorphism is associated with myocardial infarction in Mexican patients

Published: March 04, 2016
Genet. Mol. Res. 15(1): gmr7776 DOI: https://doi.org/10.4238/gmr.15017776
Cite this Article:
J.M. Rodríguez-Pérez, G. Vargas-Alarcón, R. Posadas-Sánchez, T.X. Zagal-Jiménez, R. Ortíz-Alarcón, B. Valente-Acosta, C. Tovilla-Zárate, C. Nostroza-Hernández, O. Pérez-Méndez, N. Pérez-Hernández, J.M. Rodríguez-Pérez, G. Vargas-Alarcón, R. Posadas-Sánchez, T.X. Zagal-Jiménez, R. Ortíz-Alarcón, B. Valente-Acosta, C. Tovilla-Zárate, C. Nostroza-Hernández, O. Pérez-Méndez, N. Pérez-Hernández (2016). rs3918242 MMP9 gene polymorphism is associated with myocardial infarction in Mexican patients. Genet. Mol. Res. 15(1): gmr7776. https://doi.org/10.4238/gmr.15017776
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Abstract

Several studies have demonstrated that matrix metalloproteinases (MMPs) play a major role in atherosclerotic plaque disruption and lead to myocardial infarction (MI). We investigated the association between the MMP1 -1607 1G/2G (rs1799750), MMP3 -1612 5A/6A (rs3025058), and MMP9 -1562 C/T (rs3918242) polymorphisms and the risk of developing MI in a Mexican mestizo cohort. The genotype analysis was performed using the restriction fragment length polymorphism-polymerase chain reaction technique in a group of 236 patients with a history of MI and 285 healthy controls. Similar distributions of rs1799750 and rs3025058 were observed in both groups; however, the MMP9 rs3918242 T allele and the CT genotype were associated with the risk of developing MI (OR = 2.32, pC = 0.02 and OR = 2.40, pC = 0.02, respectively). Multiple logistic analysis was performed between MI patients and controls to estimate the risk, and after adjusting for identified risk factors, the CT + TT genotypes of MMP9 rs3918242 were found to be significantly associated with increased risk of developing MI than those with the CC genotype (OR = 2.88, P < 0.01). In summary, our results reveal that the rs3918242 polymorphism of the MMP9 gene plays a major role in the risk of developing MI.

Several studies have demonstrated that matrix metalloproteinases (MMPs) play a major role in atherosclerotic plaque disruption and lead to myocardial infarction (MI). We investigated the association between the MMP1 -1607 1G/2G (rs1799750), MMP3 -1612 5A/6A (rs3025058), and MMP9 -1562 C/T (rs3918242) polymorphisms and the risk of developing MI in a Mexican mestizo cohort. The genotype analysis was performed using the restriction fragment length polymorphism-polymerase chain reaction technique in a group of 236 patients with a history of MI and 285 healthy controls. Similar distributions of rs1799750 and rs3025058 were observed in both groups; however, the MMP9 rs3918242 T allele and the CT genotype were associated with the risk of developing MI (OR = 2.32, pC = 0.02 and OR = 2.40, pC = 0.02, respectively). Multiple logistic analysis was performed between MI patients and controls to estimate the risk, and after adjusting for identified risk factors, the CT + TT genotypes of MMP9 rs3918242 were found to be significantly associated with increased risk of developing MI than those with the CC genotype (OR = 2.88, P MMP9 gene plays a major role in the risk of developing MI.