Research Article

Meta-analysis of association between IL-6 -634C/G polymorphism and osteoporosis

Published: December 29, 2015
Genet. Mol. Res. 14 (4) : 19225-19232 DOI: https://doi.org/10.4238/2015.December.29.32

Abstract

Osteoporosis is a common disease in the aging population and studies have shown that interleukin-6 (IL-6) is potentially implicated in its pathogenesis. This study was designed to assess the association between the IL-6 gene -634C/G polymorphism and osteoporosis. PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched for eligible studies published up to and including December 2014 in English or Chinese. Meta-analysis was conducted by the RevMan5.2 software. Weighted mean difference and 95% confidence interval (95%CI) were calculated by a fixed-effect or random-effect model. Bone mineral density (BMD) was regarded as the assessment index. As a result, a total of four articles with 3068 subjects were included. Differences in BMD between the CC and GG genotypes were 0.03 g/cm2 (95%CI = 0.01 to 0.05) at total body, 0.01 g/cm2 (95%CI = 0.00 to 0.03) at femoral neck, and 0.03 g/cm2 (95%CI = 0.00 to 0.06) at the lumbar spine (P 2 (95%CI = 0.02 to 0.05) at total body and 0.02 g/cm2 (95%CI = 0.00 to 0.03 at the femoral neck (P 0.05). In conclusion, the GG genotype of the -634C/G polymorphism in IL-6 appears to play a role in reducing BMD, which affects normal bone metabolism and leads to osteoporosis.

Osteoporosis is a common disease in the aging population and studies have shown that interleukin-6 (IL-6) is potentially implicated in its pathogenesis. This study was designed to assess the association between the IL-6 gene -634C/G polymorphism and osteoporosis. PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched for eligible studies published up to and including December 2014 in English or Chinese. Meta-analysis was conducted by the RevMan5.2 software. Weighted mean difference and 95% confidence interval (95%CI) were calculated by a fixed-effect or random-effect model. Bone mineral density (BMD) was regarded as the assessment index. As a result, a total of four articles with 3068 subjects were included. Differences in BMD between the CC and GG genotypes were 0.03 g/cm2 (95%CI = 0.01 to 0.05) at total body, 0.01 g/cm2 (95%CI = 0.00 to 0.03) at femoral neck, and 0.03 g/cm2 (95%CI = 0.00 to 0.06) at the lumbar spine (P 2 (95%CI = 0.02 to 0.05) at total body and 0.02 g/cm2 (95%CI = 0.00 to 0.03 at the femoral neck (P 0.05). In conclusion, the GG genotype of the -634C/G polymorphism in IL-6 appears to play a role in reducing BMD, which affects normal bone metabolism and leads to osteoporosis.