Research Article

AGER genetic polymorphisms increase risks of breast and lung cancers

Published: December 22, 2015
Genet. Mol. Res. 14 (4) : 17776-17787 DOI: 10.4238/2015.December.22.2

Abstract

We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases. Five case-control studies that investigated the correlation of AGER gene polymorphisms with BC and LC were included in the meta-analysis, representing 4337 subjects. An increased frequency of the AGER rs1800625 T>C polymorphism was observed in patients with either BC or LC. We found that the frequencies of AGER rs1800624 T>A and rs2070600 G>A variants were positively related to the risks of BC and LC under allelic models, but that these relationships were not detected under dominant models. Disease-stratified results under allelic models demonstrated that the frequencies of the AGER rs1800625 T>C and rs2070600 G>A polymorphisms were positively correlated with the susceptibility to LC, while the same correlations were not found in BC. Further subgroup analysis by genotyping method indicated that the rs1800624 T>A variant was associated with increased risks of BC and LC under a dominant model in both non-polymerase chain reaction-restriction fragment length polymorphism (non-PCR-RFLP) and PCR-RFLP subgroups. In conclusion, these data indicated that common polymorphisms in the AGER gene might increase the risks of BC and LC.

We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases. Five case-control studies that investigated the correlation of AGER gene polymorphisms with BC and LC were included in the meta-analysis, representing 4337 subjects. An increased frequency of the AGER rs1800625 T>C polymorphism was observed in patients with either BC or LC. We found that the frequencies of AGER rs1800624 T>A and rs2070600 G>A variants were positively related to the risks of BC and LC under allelic models, but that these relationships were not detected under dominant models. Disease-stratified results under allelic models demonstrated that the frequencies of the AGER rs1800625 T>C and rs2070600 G>A polymorphisms were positively correlated with the susceptibility to LC, while the same correlations were not found in BC. Further subgroup analysis by genotyping method indicated that the rs1800624 T>A variant was associated with increased risks of BC and LC under a dominant model in both non-polymerase chain reaction-restriction fragment length polymorphism (non-PCR-RFLP) and PCR-RFLP subgroups. In conclusion, these data indicated that common polymorphisms in the AGER gene might increase the risks of BC and LC.

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