Research Article

Predictive value of vascular endothelial growth factor polymorphisms on the risk of renal cell carcinomas

Published: July 13, 2015
Genet. Mol. Res. 14 (3) : 7634-7642 DOI: https://doi.org/10.4238/2015.July.13.8
Cite this Article:
(2015). Predictive value of vascular endothelial growth factor polymorphisms on the risk of renal cell carcinomas. Genet. Mol. Res. 14(3): gmr5297. https://doi.org/10.4238/2015.July.13.8
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Abstract

We conducted a case-control study in a Chinese population to assess whether 5 common single-nucleotide polymor­phisms in the vascular endothelial growth factor gene (VEGF) affect the risk of renal cell carcinoma (RCC). The study population in­cluded 266 RCC patients who were newly diagnosed and histologi­cally confirmed to have RCC as well as 532 cancer-free controls. Genotyping of VEGF -2578C/A, -1156G/A, +1612G/A, +936C/T, and -634G/C was conducted by polymerase chain reaction-restric­tion fragment length polymorphism. RCC patients were more likely to have higher body mass index, and have a habit of tobacco smok­ing as well as suffer from diabetes. Conditional logistic regression analyses showed that individuals with the AA genotype and A allele of -2578C/A significantly increased the risk of RCC when compared with the CC genotype. Individuals carrying the CT and TT geno­types of +936C/T were correlated with an increased risk of RCC compared to the CC genotype. The T allele of +936C/T was associ­ated with an increased risk of RCC. The -2578C/A and +936C/T polymorphisms in the VEGF gene may play a role in the etiology of RCC.

We conducted a case-control study in a Chinese population to assess whether 5 common single-nucleotide polymor­phisms in the vascular endothelial growth factor gene (VEGF) affect the risk of renal cell carcinoma (RCC). The study population in­cluded 266 RCC patients who were newly diagnosed and histologi­cally confirmed to have RCC as well as 532 cancer-free controls. Genotyping of VEGF -2578C/A, -1156G/A, +1612G/A, +936C/T, and -634G/C was conducted by polymerase chain reaction-restric­tion fragment length polymorphism. RCC patients were more likely to have higher body mass index, and have a habit of tobacco smok­ing as well as suffer from diabetes. Conditional logistic regression analyses showed that individuals with the AA genotype and A allele of -2578C/A significantly increased the risk of RCC when compared with the CC genotype. Individuals carrying the CT and TT geno­types of +936C/T were correlated with an increased risk of RCC compared to the CC genotype. The T allele of +936C/T was associ­ated with an increased risk of RCC. The -2578C/A and +936C/T polymorphisms in the VEGF gene may play a role in the etiology of RCC.

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