Research Article

Impact of early postoperative enteral nutrition on clinical outcomes in patients with gastric cancer

Published: June 29, 2015
Genet. Mol. Res. 14 (2) : 7136-7141 DOI: 10.4238/2015.June.29.7

Abstract

The impact of early enteral nutrition (EEN) on clinical outcomes of gastric cancer patients was investigated. Three hundred pa­tients undergoing gastric cancer surgery from July 2010 to May 2014 were randomly divided into experimental and control groups (n = 150/group). Experimental group patients received enteral nutrition in water during the early postoperative period. Control group patients received conventional perioperative treatment. Patients’ clinical outcomes, post­operative immune function, and nutritional statuses were compared, which revealed that the postoperative fever duration (80.2 ± 6.0 vs 88.1 ± 8.1 h, P vs 85.3 ± 8.4 h, P vs 9.77 ± 1.76 days, P vs 17.3% (26/150), P > 0.05]. At postoperative days 3 and 7, the CD3+, CD4+, natural killer cell, albumin, and prealbumin levels and CD4+/CD8+ ra­tio were significantly higher in the experimental group than the control group (all P + cell counts were significantly lower in the experimental group than the control group (P

The impact of early enteral nutrition (EEN) on clinical outcomes of gastric cancer patients was investigated. Three hundred pa­tients undergoing gastric cancer surgery from July 2010 to May 2014 were randomly divided into experimental and control groups (n = 150/group). Experimental group patients received enteral nutrition in water during the early postoperative period. Control group patients received conventional perioperative treatment. Patients’ clinical outcomes, post­operative immune function, and nutritional statuses were compared, which revealed that the postoperative fever duration (80.2 ± 6.0 vs 88.1 ± 8.1 h, P vs 85.3 ± 8.4 h, P vs 9.77 ± 1.76 days, P vs 17.3% (26/150), P > 0.05]. At postoperative days 3 and 7, the CD3+, CD4+, natural killer cell, albumin, and prealbumin levels and CD4+/CD8+ ra­tio were significantly higher in the experimental group than the control group (all P + cell counts were significantly lower in the experimental group than the control group (P