Research Article

Apelin polymorphism predicts blood pressure response to losartan in older Chinese women with essential hypertension

Published: June 12, 2015
Genet. Mol. Res. 14 (2) : 6561-6568 DOI: https://doi.org/10.4238/2015.June.12.10
Cite this Article:
(2015). Apelin polymorphism predicts blood pressure response to losartan in older Chinese women with essential hypertension. Genet. Mol. Res. 14(2): gmr5618. https://doi.org/10.4238/2015.June.12.10
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Abstract

We determined whether the blood pressure response to losartan in an older Chinese population with essential hypertension was associated with apelin gene polymorphisms. We genotyped the -1860T>C polymorphism of the apelin gene in a case-control study of 222 patients with hypertension and 250 controls. Following 24 weeks of treatment with losartan (50 mg/day), reductions in systolic blood pressure were significantly different among the additive (CT vs CC vs TT), dominant (TT vs CC/CT), and recessive models (CC vs CT/TT; all P C genotype may play an important predictive role in the response to losartan in hypertensive women.

We determined whether the blood pressure response to losartan in an older Chinese population with essential hypertension was associated with apelin gene polymorphisms. We genotyped the -1860T>C polymorphism of the apelin gene in a case-control study of 222 patients with hypertension and 250 controls. Following 24 weeks of treatment with losartan (50 mg/day), reductions in systolic blood pressure were significantly different among the additive (CT vs CC vs TT), dominant (TT vs CC/CT), and recessive models (CC vs CT/TT; all P C genotype may play an important predictive role in the response to losartan in hypertensive women.

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