Research Article

Health and production traits in bovine are associated with single nucleotide polymorphisms in the NOD2 gene

Published: April 17, 2015
Genet. Mol. Res. 14 (2) : 3570-3578 DOI: https://doi.org/10.4238/2015.April.17.6
Cite this Article:
(2015). Health and production traits in bovine are associated with single nucleotide polymorphisms in the NOD2 gene. Genet. Mol. Res. 14(2): gmr4917. https://doi.org/10.4238/2015.April.17.6
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Abstract

The NOD2 gene plays a fundamental role in initiating the inflammatory and subsequent immune response. NOD2 was previously identified as a susceptibility locus for inflammatory bowel diseases in humans. In this study, we detected 2 mutations in exon 12 (A→T, G→A) among 5 cattle breeds (N = 315) and analyzed their associations with production traits and genetic resistance against bovine mastitis in Chinese Holstein and Chinese Simmental breeds (N = 218). The transitions (A→T) at position 114 bp were associated with somatic cell score (P

The NOD2 gene plays a fundamental role in initiating the inflammatory and subsequent immune response. NOD2 was previously identified as a susceptibility locus for inflammatory bowel diseases in humans. In this study, we detected 2 mutations in exon 12 (A→T, G→A) among 5 cattle breeds (N = 315) and analyzed their associations with production traits and genetic resistance against bovine mastitis in Chinese Holstein and Chinese Simmental breeds (N = 218). The transitions (A→T) at position 114 bp were associated with somatic cell score (P