Research Article

Clinical study on gastric cancer susceptibility genes IL-10-1082 and TNF-α

Published: December 19, 2014
Genet. Mol. Res. 13 (4) : 10909-10912 DOI: 10.4238/2014.December.19.12

Abstract

TNF 308 gene polymorphism and IL-10 polymorphism provided evidence in diagnosing some types of cancer. We aimed to explore the relation of gene polymorphism with gastric cancer. A total of 360 cases of gastric cancer patients were included in the study. The genotypes GG, GA, and AA of the interleukin-10-1082 gene (IL-10-1082) and the tumor necrosis factor-alpha gene (TNF-α) 308 polymorphism were examined by chromogenic detection. Three hundred healthy individuals’ gene as control group were also examined. The GA 308 genotype of TNF-αdiffered significantly between the control group and the gastric cancer group (X2 = 9.32, P IL-10-1082 gene polymorphism in the gastric cancer group differed significantly compared to those of the control group (X2 = 20.32, P IL-10-1082 gene and the GA 308 genotype of the TNF-αgene were found to be susceptibility genes for gastric cancer.

TNF 308 gene polymorphism and IL-10 polymorphism provided evidence in diagnosing some types of cancer. We aimed to explore the relation of gene polymorphism with gastric cancer. A total of 360 cases of gastric cancer patients were included in the study. The genotypes GG, GA, and AA of the interleukin-10-1082 gene (IL-10-1082) and the tumor necrosis factor-alpha gene (TNF-α) 308 polymorphism were examined by chromogenic detection. Three hundred healthy individuals’ gene as control group were also examined. The GA 308 genotype of TNF-αdiffered significantly between the control group and the gastric cancer group (X2 = 9.32, P IL-10-1082 gene polymorphism in the gastric cancer group differed significantly compared to those of the control group (X2 = 20.32, P IL-10-1082 gene and the GA 308 genotype of the TNF-αgene were found to be susceptibility genes for gastric cancer.

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