Research Article

Association of c.461G>A genetic variant of OGG1 gene with pancreatic cancer susceptibility in Chinese

Published: September 05, 2014
Genet. Mol. Res. 13 (3) : 7256-7261 DOI: 10.4238/2014.September.5.10

Abstract

This study aimed to evaluate the potential association of single nucleotide polymorphisms of the 8-oxoguanine DNA glycosylase gene (OGG1) with susceptibility to pancreatic cancer (PC). A total of 764 Chinese Han subjects were recruited in this study. The polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing methods were used to detect the genotype of c.461G>A genetic variant of OGG1. The genotype and allele frequencies were statistically different in PC patients compared with cancer-free controls. The AA genotype was statistically associated with increased PC susceptibility compared to GG wild genotype (AA vs GG, OR = 2.62, 95%CI = 1.48-4.63, χ2 = 11.46, P = 0.001). Allele A could contribute to the increased risk of PC (A vs G, OR = 1.35, 95%CI = 1.08-1.69, χ2 = 6.86, P = 0.009). Our data indicated that the c.461G>A genetic variant of the OGG1 gene was associated with susceptibility to PC in a Chinese Han population.

This study aimed to evaluate the potential association of single nucleotide polymorphisms of the 8-oxoguanine DNA glycosylase gene (OGG1) with susceptibility to pancreatic cancer (PC). A total of 764 Chinese Han subjects were recruited in this study. The polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing methods were used to detect the genotype of c.461G>A genetic variant of OGG1. The genotype and allele frequencies were statistically different in PC patients compared with cancer-free controls. The AA genotype was statistically associated with increased PC susceptibility compared to GG wild genotype (AA vs GG, OR = 2.62, 95%CI = 1.48-4.63, χ2 = 11.46, P = 0.001). Allele A could contribute to the increased risk of PC (A vs G, OR = 1.35, 95%CI = 1.08-1.69, χ2 = 6.86, P = 0.009). Our data indicated that the c.461G>A genetic variant of the OGG1 gene was associated with susceptibility to PC in a Chinese Han population.