Research Article

Protection from vascular endothelial dysfunction in acute glycemic load-induced primary hypertension by vitamin C and E

Published: September 05, 2014
Genet. Mol. Res. 13 (3) : 7246-7255 DOI: 10.4238/2014.September.5.9

Abstract

This study aimed to investigate the influence of acute glycemic load on vascular endothelial function in patients with hypertension and to evaluate the protective effect of vitamins C and E during the acute glycemic phase. We randomly selected 39 hypertensive patients and 21 normal subjects and divided them into 3 groups: 75 g oral glucose (glycemic load group), 75 g glucose + 0.9 g vitamin C (VC group), 75 g glucose + 2 g vitamin C + 0.8 g vitamin E (VC + VE group). Extravascular color Doppler ultrasound was used to detect brachial artery flow-mediated vasodilation at 0, 1, 2, and 3 h, and, at the same time, serum anti-oxidant products were measured. Basic endothelial functions in patients with hypertension were decreased in the glycemic load group (9.48 ± 3.33 versus 13.09 ± 6.78%, P

This study aimed to investigate the influence of acute glycemic load on vascular endothelial function in patients with hypertension and to evaluate the protective effect of vitamins C and E during the acute glycemic phase. We randomly selected 39 hypertensive patients and 21 normal subjects and divided them into 3 groups: 75 g oral glucose (glycemic load group), 75 g glucose + 0.9 g vitamin C (VC group), 75 g glucose + 2 g vitamin C + 0.8 g vitamin E (VC + VE group). Extravascular color Doppler ultrasound was used to detect brachial artery flow-mediated vasodilation at 0, 1, 2, and 3 h, and, at the same time, serum anti-oxidant products were measured. Basic endothelial functions in patients with hypertension were decreased in the glycemic load group (9.48 ± 3.33 versus 13.09 ± 6.78%, P

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