Research Article

Racial disparities in the association between diabetes mellitus-associated polymorphic locus rs4430796 of the HNF1βgene and prostate cancer: a systematic review and meta-analysis

Published: August 28, 2014
Genet. Mol. Res. 13 (3) : 6582-6592 DOI: 10.4238/2014.August.28.3

Abstract

Polymorphism 17q12 rs4430796 within HNF1βis a genetic variant associated with both diabetes mellitus and prostate cancer, but findings on the correlations of rs4430796 with prostate cancer risk specifically are not in agreement, especially among diverse populations. To shed some light on the contradictory findings, therefore, we carried out a meta-analysis by pooling the odds ratios (ORs) with corresponding 95% confidence intervals (CIs) of all currently available case-control studies located within PubMed and Embase databases up to December 2012. A total of 16 studies comprising 30 datasets that collectively involved 25,535 prostate cancer patients and 25,726 controls were ultimately included in this analysis. The meta-analysis of all the studies revealed that the rs4430796 polymorphism was significantly associated with an increased risk of prostate cancer in all contrast models (ORA vs G = 1.25, 95%CI = 1.21-1.30, POR AA vs GG = 1.53, 95%CI = 1.45-1.62, POR AG vs GG = 1.24, 95%CI = 1.16-1.34, POR AA vs AG+GG = 1.36, 95%CI = 1.30-1.42, POR AA+AG vs GG = 1.37, 95%CI = 1.30-1.44, POR

Polymorphism 17q12 rs4430796 within HNF1βis a genetic variant associated with both diabetes mellitus and prostate cancer, but findings on the correlations of rs4430796 with prostate cancer risk specifically are not in agreement, especially among diverse populations. To shed some light on the contradictory findings, therefore, we carried out a meta-analysis by pooling the odds ratios (ORs) with corresponding 95% confidence intervals (CIs) of all currently available case-control studies located within PubMed and Embase databases up to December 2012. A total of 16 studies comprising 30 datasets that collectively involved 25,535 prostate cancer patients and 25,726 controls were ultimately included in this analysis. The meta-analysis of all the studies revealed that the rs4430796 polymorphism was significantly associated with an increased risk of prostate cancer in all contrast models (ORA vs G = 1.25, 95%CI = 1.21-1.30, POR AA vs GG = 1.53, 95%CI = 1.45-1.62, POR AG vs GG = 1.24, 95%CI = 1.16-1.34, POR AA vs AG+GG = 1.36, 95%CI = 1.30-1.42, POR AA+AG vs GG = 1.37, 95%CI = 1.30-1.44, POR