Research Article

Transcriptional analysis of the porcine TTID gene and association of different TTID genotypes with carcass traits

Published: February 27, 2014
Genet. Mol. Res. 13 (1) : 1195-1202 DOI: https://doi.org/10.4238/2014.February.27.4
Cite this Article:
J. Wang, Y.P. Feng, B. Zuo, Y.Z. Xiong, C.Y. Deng (2014). Transcriptional analysis of the porcine TTID gene and association of different TTID genotypes with carcass traits. Genet. Mol. Res. 13(1): 1195-1202. https://doi.org/10.4238/2014.February.27.4
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Abstract

The titin immunoglobulin domain (TTID) protein localizes to the Z line in muscle and binds to alpha-actinin and gamma-filamin. It plays an indispensable role in stabilizing and anchoring of thin filaments. In this study, the 5'-regulatory region of the porcine TTID gene was analyzed with bioinformatic methods. Another objective of this study was to further investigate the polymorphism in the intron 6 of the porcine TTID gene. We determined allele frequency among six Chinese porcine purebreds. The polymorphisms were genotyped in a population of 280 F2 pigs representing two Large White x Meishan reference families. Different TTID genotypes were significantly associated with carcass traits, including skin percentage (P < 0.05), loin eye area (P < 0.05), and average skin thickness (P < 0.01). Our study will continue to lay the groundwork for further investigations into the detailed function of the porcine TTID gene.

The titin immunoglobulin domain (TTID) protein localizes to the Z line in muscle and binds to alpha-actinin and gamma-filamin. It plays an indispensable role in stabilizing and anchoring of thin filaments. In this study, the 5'-regulatory region of the porcine TTID gene was analyzed with bioinformatic methods. Another objective of this study was to further investigate the polymorphism in the intron 6 of the porcine TTID gene. We determined allele frequency among six Chinese porcine purebreds. The polymorphisms were genotyped in a population of 280 F2 pigs representing two Large White x Meishan reference families. Different TTID genotypes were significantly associated with carcass traits, including skin percentage (P TTID gene.