Research Article

Marsdenia tenacissima extract sensitizes MG63 cells to doxorubicin-induced apoptosis

Published: January 21, 2014
Genet. Mol. Res. 13 (1) : 354-362 DOI: https://doi.org/10.4238/2014.January.21.3
Cite this Article:
(2014). Marsdenia tenacissima extract sensitizes MG63 cells to doxorubicin-induced apoptosis. Genet. Mol. Res. 13(1): gmr2906. https://doi.org/10.4238/2014.January.21.3
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Abstract

Marsdenia tenacissima extract (MTE) is a new plate-derived biotechnology product that is frequently used, but occasionally reported, in the field of chemotherapy. In this study, we assessed the antitumor activity and related mechanisms of MTE by various biotechnological methods. The survival rates of MG63 osteosarcoma cells treated with MTE and doxorubicin were measured, individually or jointly, and the changes in cellular shape, apoptotic rates, and Fas expression were observed. The results indicated that combination of MTE and doxorubicin up-regulated Fas expression and induced apoptosis. The survival rate of combined application of 50 mg/mL MTE and 1 μg/mL doxorubicin was significantly lower than that of the individual application (P

Marsdenia tenacissima extract (MTE) is a new plate-derived biotechnology product that is frequently used, but occasionally reported, in the field of chemotherapy. In this study, we assessed the antitumor activity and related mechanisms of MTE by various biotechnological methods. The survival rates of MG63 osteosarcoma cells treated with MTE and doxorubicin were measured, individually or jointly, and the changes in cellular shape, apoptotic rates, and Fas expression were observed. The results indicated that combination of MTE and doxorubicin up-regulated Fas expression and induced apoptosis. The survival rate of combined application of 50 mg/mL MTE and 1 μg/mL doxorubicin was significantly lower than that of the individual application (P